Detects many solid organ tumors of the neck, chest, abdomen, and pelvis to increase chances of early detection with certain cancers and optimize treatments.
Sequencing provides enormous amounts of information about the role of inheritance in your susceptibility to disease including single gene mutations that cause cystic fibrosis, hypercholesterolemia and sickle cell anemia or polygenic mutations that are associated with the development of breast, colon, esophageal, and pancreatic cancer, Alzheimer’s and Parkinson’s disease, atrial fibrillation, and more.
MRI uses powerful magnets, radio waves, and computer technology to generate detailed images of your organs without the use of radiation. Human Longevity MRI protocols are uniquely beneficial because they employ proprietary software that produces contrast quality imaging without the injection of contrast media. This software aids in the early detection of cancer, cardiac disease, metabolic and neurodegenerative disease.
Detects many solid organ tumors of the neck, chest, abdomen, and pelvis to increase chances of early detection with certain cancers and optimize treatments.
Generates detailed visualization of the soft tissues and vessels of the brain enabling early intervention for structural, volumetric and vascular abnormalities including tumors, neurodegeneration (Alzheimer’s or Parkinson’s disease) brain vessel narrowing or aneurysms.
Provides 3D structural and functional information about the heart, including left ventricle ejection fraction, heart wall motion, and valvular evaluation for prevention and treatment of disease. (Cardiac MRI is not designed to evaluate the coronary arteries.)
Precision medicine integrating whole-genome sequencing, comprehensive metabolomics, and advanced imaging
Significance
To understand the value and clinical impact of surveying genome-wide disease-causing genes and variants, we used a prospective cohort study design that enrolled volunteers who agreed to have their whole genome sequenced and to participate in deep phenotyping using clinical laboratory tests, metabolomics technologies, and advanced noninvasive imaging. The genomic results are integrated with the phenotype results. Approximately 1 in 6 adult individuals (17.3%) had genetic findings and, when integrated with deep phenotyping data, including family/medical histories with genetic findings, 1 in 9 (11.5%) had genotype and phenotype associations. Genomics and metabolomics association analysis revealed 5.1% of heterozygotes with phenotype manifestations affecting serum metabolite levels. We report observations from our study…
Read our breakthrough PNAS publication by downloading the PDF here.
Dr. Keen is the Chief of Cardiology and Medical Director of Human Longevity, San Diego. With over two decades of clinical, administrative, and academic experience and contributions to clinical cardiology. His passion is early detection of clinical and pre-clinical heart disease. Prior to Human Longevity, Dr. Keen was the chief of echocardiography, chief of the adult congential heart disease program, chief of the department of internal medicine, and assistant medical director over the departments of emergency medicine, hospital medicine, critical care, radiology, laboratory and pathology, and continuing care at Kaiser Permanente.
An internationally recognized innovative leader in MR imaging and genomic analytics, Dr. Karow is a proponent of using data-driven precision medicine testing and AI to achieve extensions in the healthy human lifespan. He is the senior author and co-author of numerous publications focused on early detection of chronic age-related disease using imaging and genomic biomarkers. Dr. Karow graduated from medical school at the University of Michigan, Ann Arbor in 2005 in a combined MD/PhD program with a distinction in research and completed residency and fellowship at UC San Diego and UC Los Angeles, respectively. David currently serves as President and Chief of Radiology.
With over a decade of clinical research experience at institutions such as National Cancer Institute, FDA, Clinical Center at National Institutes of Health, Mount Sinai, USC, and UC Irvine, Dr. Julie Chen is the Chief Clinical Officer for Human Longevity and Medical Director of Human Longevity, San Francisco. She has been featured on TV as a medical expert on shows like Dr. Oz, The Doctors, KABC-LA, Chicago Fox 32 News, and more. Additionally, Dr. Julie Chen has been published in national magazines and websites, such as HuffingtonPost.com, Men’s Health, MSN.com, Healthline.com.