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Diagnostic

Sequencing provides enormous amounts of information about the role of inheritance in your susceptibility to disease including single gene mutations that cause cystic fibrosis, hypercholesterolemia and sickle cell anemia or polygenic mutations that are associated with the development of breast, colon, esophageal, and pancreatic cancer, Alzheimer’s and Parkinson’s disease, atrial fibrillation, and more.

Whole Genome Sequencing & Updating

  • Evaluation of current risk for disease
  • Carrier status for conditions you may pass on to future generations
  • Pharmacogenomic profile  (your response/non-response to certain medications).
  • Physical traits and attributes that can guide lifestyle decisions
  • Future risk for disease based upon annual comparison of your genome with the Human Longevity growing genomic database and the rapidly evolving body of research associated with on-going global discovery

MRI (Magnetic Resonance Imaging)

MRI uses powerful magnets, radio waves, and computer technology to generate detailed images of your organs without the use of radiation. Human Longevity MRI protocols are uniquely beneficial because they employ proprietary software that produces contrast quality imaging without the injection of contrast media. This software aids in the early detection of cancer, cardiac disease, metabolic and neurodegenerative disease.

01Body

Detects many solid organ tumors of the neck, chest, abdomen, and pelvis to increase chances of early detection with certain cancers and optimize treatments.

02Brain

Generates detailed visualization of the soft tissues and vessels of the brain enabling early intervention for structural, volumetric and vascular abnormalities including tumors, neurodegeneration (Alzheimer’s or Parkinson’s disease) brain vessel narrowing or aneurysms.

03Heart

Provides 3D structural and functional information about the heart, including left ventricle ejection fraction, heart wall motion, and valvular evaluation for prevention and treatment of disease. (Cardiac MRI is not designed to evaluate the coronary arteries.)

Additional Diagnostics

Coronary Calcium Score* (CT)

Non-Contrast Cardiac CT assesses coronary artery health by detecting the location and extent of calcified plaque in the walls of your coronary arteries. It is a key factor used in the calculation of current and future cardiovascular risk.

Echocardiogram (ECHO)

Uses ultrasound to visualize and measure the size and shape of your heart, the pumping strength of the left ventricle (ejection fraction) and the real time opening and closing of heart valves. Can indicate the emergence of heart valve disease, left ventricular failure and thickening (hypertrophy) of heart muscle for treatment purposes.

Electrocardiogram (ECG)

Measures the pattern and wave of electrical energy that travels through the conduction system of the heart indicating whether the heartbeat is normal, slow, fast or irregular. Can also indicate heart muscle thickening or fatigue for clinical management.

Wireless Heart Rhythm

Cardiac monitor placement on the upper left chest records up to two weeks of continuous heart rhythm activity. Information can aid in the detection and treatment of arrhythmias known to be a major cause of stroke.

Balance Tracker

Computes upper body movements (postural sway) that occur when trying to maintain balance during walking. Assesses balance and performance activities to prevent falls and improve physical activity and vitality.

Comprehensive Labs and Metabolic Analysis

Analysis and reporting of over 40 blood biomarkers testing for anemia and iron status, liver and kidney function, insulin and glucose markers, cholesterol panel with particle size, inflammatory markers, hormones, heavy metals, and certain vitamin nutrient levels.

Insulin Sensitivity Testing

Insulin helps control the amounts of sugar (glucose) in the blood. With insulin resistance, cellular absorption of glucose is impaired and blood sugar levels rise. Treatment is then targeted to avoid progression to Type 2 diabetes.

Dexa* (Dual X-ray absorptiometry)

Measures bone mineral density and bone strength. Assessment enables the treatment of osteoporosis to prevent fractures.

Metabolomics

Lab measurement of over 900 metabolites—the by-products or residue of bio-chemical reactions that remain in the blood after the metabolism of food and drugs. When balance is disturbed by disease, genetic mutations or environmental factors, one’s metabolic profile changes making metabolites informative biomarkers for understanding disease, toxicity, drug interactions and other factors that impact health.

Multi Targeted Stool DNA Test*

A self-administered, FDA-approved colorectal screening kit for home use, designed to provide an indication of the presence of cancer.

Body Composition

Assessment precisely quantifies visceral fat (fat stored within the abdominal cavity) and thigh muscle composition. The ratio of fat to muscle may indicate a risk for metabolic syndrome which can lead to heart disease, stroke, type 2 diabetes, breast and colon cancer as well as Alzheimer’s disease.

Sensors

Monitors for day to day health metrics. These could include continuous glucose monitors (CGM), sleep trackers, blood pressure monitors or others. With this data, we can optimize areas of nutrition, sleep, diet, and exercise.

Publications

03.23.22

PNAS publication

Precision medicine integrating whole-genome sequencing, comprehensive metabolomics, and advanced imaging

Significance

To understand the value and clinical impact of surveying genome-wide disease-causing genes and variants, we used a prospective cohort study design that enrolled volunteers who agreed to have their whole genome sequenced and to participate in deep phenotyping using clinical laboratory tests, metabolomics technologies, and advanced noninvasive imaging. The genomic results are integrated with the phenotype results. Approximately 1 in 6 adult individuals (17.3%) had genetic findings and, when integrated with deep phenotyping data, including family/medical histories with genetic findings, 1 in 9 (11.5%) had genotype and phenotype associations. Genomics and metabolomics association analysis revealed 5.1% of heterozygotes with phenotype manifestations affecting serum metabolite levels. We report observations from our study…

Read our breakthrough PNAS publication by downloading the PDF here.

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Medical Board

Dr. William Keen

Chief of Cardiology and Medical Director

Bio

Dr. Keen is the Chief of Cardiology and Medical Director of Human Longevity, San Diego. With over two decades of clinical, administrative, and academic experience and contributions to clinical cardiology. His passion is early detection of clinical and pre-clinical heart disease. Prior to Human Longevity, Dr. Keen was the chief of echocardiography, chief of the adult congential heart disease program, chief of the department of internal medicine, and assistant medical director over the departments of emergency medicine, hospital medicine, critical care, radiology, laboratory and pathology, and continuing care at Kaiser Permanente. 

Education
  • BS,  Pharmacy.  The University of Sciences in Philadelphia, Philadelphia, PA
  • MD, Rutgers New Jersey Medical School, Newark, NJ
  • Residency, Internal Medicine.  Harvard Affiliated Beth Israel Deaconess Medical Center, Boston, MA
  • Residency, Internal Medicine.  Thomas Jefferson University Hospital, Philadelphia, PA
  • Fellowship, Cardiovascular Diseases.  Thomas Jefferson University Hospital, Philadelphia, PA2014 Executive Leadership Program.  Harvard Business School.  Boston, MA
Accreditations
  • Medical Board of California, Physician and Surgeon
    Certified, American Board of Internal Medicine
  • Certified, American Board of Internal Medicine, Cardiovascular Diseases
  • Fellow, The American College of Cardiology (FACC)
  • Voluntary Clinical Professor of Medicine, The University of California, San Diego
  • San Diego Medical Society – Top Doctor
  • American Society of Echocardiography
  • Advanced Cardiac Life Support Certification

Dr. David Karow

President and Chief of Radiology

Bio

An internationally recognized innovative leader in MR imaging and genomic analytics, Dr. Karow is a proponent of using data-driven precision medicine testing and AI to achieve extensions in the healthy human lifespan. He is the senior author and co-author of numerous publications focused on early detection of chronic age-related disease using imaging and genomic biomarkers. Dr. Karow graduated from medical school at the University of Michigan, Ann Arbor in 2005 in a combined MD/PhD program with a distinction in research and completed residency and fellowship at UC San Diego and UC Los Angeles, respectively. David currently serves as President and Chief of Radiology.

Education
  • B.S, University of Michigan, Concentration: Cellular and Molecular Biology MD, PH.D in Cellular and Molecular Biology  University of Michigan
  • Internship in Internal Medicine, University of California, Irvine
  • Residency in Diagnostic Radiology, University of California, San Diego
  • Fellowship in Abdominal Imaging and Cross-sectional Interventional, University of California, Los Angeles
Accreditations
  • Medical Board of California
  • Physician and Surgeon Board Certified
  • American Board of Radiology
  • Diagnostic California X-Ray Supervisor & Operator Permit

Dr. Julie Chen

Chief Clinical Officer for Human Longevity and Medical Director

Bio

With over a decade of clinical research experience at institutions such as National Cancer Institute, FDA, Clinical Center at National Institutes of Health, Mount Sinai, USC, and UC Irvine, Dr. Julie Chen is the Chief Clinical Officer for Human Longevity and Medical Director of Human Longevity, San Francisco. She has been featured on TV as a medical expert on shows like Dr. Oz, The Doctors, KABC-LA, Chicago Fox 32 News, and more. Additionally, Dr. Julie Chen has been published in national magazines and websites, such as HuffingtonPost.com, Men’s Health, MSN.com, Healthline.com.

Education
  • University of Arizona, Tucson, Arizona: Arizona Center of Integrative Medicine, Integrative Medicine Fellowship
  • California Pacific Medical Center: San Francisco, California:Department of Internal Medicine, Internal Medicine Residency
  • University of Rochester School of Medicine and Dentistry, Rochester, New York: Rochester Early Medical Scholar eight-year B.A-M.D. Program; Degree: M.D. with Distinction in Research
  • University of Rochester, Rochester, New York: Rochester Early Medical Scholar eight-year B.A.-M.D. Program; Degree: B.A. in Public Health
Accreditations
  • Board Certified in Integrative Medicine: American Board of Integrative and Holistic Medicine
  • University of Arizona Integrative Medicine Fellowship
  • HeartMath Training for Heart Rate Variability Biofeedback Completed
  • The Jones Institute Certification for Osteopathic Manipulations
  • Palo Alto School of Hypnotherapy Certification for Clinical Hypnotherapy
  • Board Certified in Internal Medicine American Board of Internal Medicine